解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Hibernation is a physiological state exploited by many animals exposed to prolonged adverse environmental conditions associated with winter. Large changes in metabolism and cellular function occur, with many stress response pathways modulated to tolerate physiological challenges that might otherwise be letha...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5750-x
更新日期:2019-06-06 00:00:00
abstract:BACKGROUND:Long terminal repeat retrotransposons are the most abundant transposons in plants. They play important roles in alternative splicing, recombination, gene regulation, and defense mechanisms. Large-scale sequencing projects for plant genomes are currently underway. Software tools are important for annotating l...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5796-9
更新日期:2019-06-03 00:00:00
abstract:BACKGROUND:The importance of Indian germplasm as origin and primary center of diversity of cultivated melon is widely accepted. Genetic diversity of several collections from Indian has been studied previously, although an integrated analysis of these collections in a global diversity perspective has not been possible. ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5784-0
更新日期:2019-06-03 00:00:00
abstract:BACKGROUND:Habitats colonized by acidophiles as an ideal physical barrier may induce genetic exchange of microbial members within the common communities, but little is known about how species in extremely acidic environments diverge and evolve. RESULTS:Using the acidophilic sulfur-oxidizer Acidithiobacillus as a case ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5827-6
更新日期:2019-05-30 00:00:00
abstract:BACKGROUND:BCG is the most widely used vaccine of all time and remains the only licensed vaccine for use against tuberculosis in humans. BCG also protects other species such as cattle against tuberculosis, but due to its incompatibility with current tuberculin testing regimens remains unlicensed. BCG's efficacy relates...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5791-1
更新日期:2019-05-28 00:00:00
abstract:BACKGROUND:The golden birdwing butterfly (Troides aeacus formosanus) is a rarely observed species in Taiwan. Recently, a typical symptom of nuclear polyhedrosis was found in reared T. aeacus larvae. From the previous Kimura-2 parameter (K-2-P) analysis based on the nucleotide sequence of three genes in this isolate, po...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5713-2
更新日期:2019-05-27 00:00:00
abstract:BACKGROUND:Cotton (Gossypium spp.) is the most important natural fiber crop worldwide, and cottonseed oil is its most important byproduct. Phospholipid: diacylglycerol acyltransferase (PDAT) is important in TAG biosynthesis, as it catalyzes the transfer of a fatty acyl moiety from the sn-2 position of a phospholipid to...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5728-8
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:Previous investigations of phylogeny in Cervus recovered many clades without whole genomic support. METHODS:In this study, the genetic diversity and phylogeny of 5 species (21 subspecies/populations from C. unicolor, C. albirostris, C. nippon, C. elaphus and C. eldii) in the genus Cervus were analyzed using...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5785-z
更新日期:2019-05-17 00:00:00
abstract:BACKGROUND:Toxigenic Vibrio cholerae serogroup O1 is the causative pathogen in the sixth and seventh cholera pandemics. Cholera toxin is the major virulent factor but other virulence and virulence-related factors play certain roles in the pathogenesis and survival in the host. Along with the evolution of the epidemic s...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5725-y
更新日期:2019-05-09 00:00:00
abstract:BACKGROUND:Bacteriophages are the most abundant and diverse entities in the biosphere, and this diversity is driven by constant predator-prey evolutionary dynamics and horizontal gene transfer. Phage genome sequences are under-sampled and therefore present an untapped and uncharacterized source of genetic diversity, ty...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5647-8
更新日期:2019-05-09 00:00:00
abstract:BACKGROUND:In natural environments, bacteria must frequently cope with extremely scarce nutrients. Most studies focus on bacterial growth in nutrient replete conditions, while less is known about the stationary phase. Here, we are interested in global gene expression throughout all growth phases, including the adjustme...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5749-3
更新日期:2019-05-09 00:00:00
abstract:BACKGROUND:Evolution leaves an imprint in species through genetic change. At the molecular level, evolutionary changes can be explored by studying ratios of nucleotide substitutions. The interplay among molecular evolution, derived phenotypes, and ecological ranges can provide insights into adaptive radiations. Caecili...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5694-1
更新日期:2019-05-09 00:00:00
abstract:BACKGROUND:Histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 lysine 9 tri-methylation (H3K9me3) are widely perceived to be opposing and often mutually exclusive chromatin modifications. However, both are needed for certain light-activated genes in Neurospora crassa (Neurospora), including frequency (frq) and...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5729-7
更新日期:2019-05-08 00:00:00
abstract:BACKGROUND:Caixin and Zicaitai (Brassica rapa) belong to Southern and Central China respectively. Zicaitai contains high amount of anthocyanin in leaf and stalk resulting to the purple color. Stalk is the major edible part and stalk color is an economically important trait for the two vegetables. The aim of this study ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5693-2
更新日期:2019-05-07 00:00:00
abstract:BACKGROUND:Bacillus pumilus is a Gram-positive and endospore-forming bacterium broadly existing in a variety of environmental niches. Because it produces and secrets many industrially useful enzymes, a lot of studies have been done to understand the underlying mechanisms. Among them, scoC was originally identified as a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5671-8
更新日期:2019-04-30 00:00:00
abstract:BACKGROUND:Salinity is an abiotic stress that negatively affects soybean [Glycine max (L.) Merr.] seed yield. Although a major gene for salt tolerance was identified and consistently mapped to chromosome (Chr.) 3 by linkage mapping studies, it does not fully explain genetic variability for tolerance in soybean germplas...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5662-9
更新日期:2019-04-25 00:00:00
abstract:BACKGROUND:Gene duplication underlies a significant proportion of gene functional diversity and genome complexity in both eukaryotes and prokaryotes. Although several reports in the literature described the duplication of specific genes in E. coli, a detailed analysis of the extent of gene duplications in this microorg...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5683-4
更新日期:2019-04-24 00:00:00
abstract:BACKGROUND:Evolutionary theory indicates that the dynamics of aging in the soma and reproductive tissues may be distinct. This difference arises from the fact that only the germline lineage establishes future generations. In the soma, changes in the landscape of heterochromatin have been proposed to have an important r...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5668-3
更新日期:2019-04-23 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs that play important roles by regulating other genes. Rosa rugosa Thunb. is an important ornamental and edible plant, yet there are only a few studies on the miRNAs and their functions in R. rugosa. RESULTS:We sequenced 10 samll RNA profiles from the roots, petals...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5325-2
更新日期:2019-04-18 00:00:00
abstract:BACKGROUND:Fragile sites are the chromosomal regions that are susceptible to breakage, and their frequency varies among the human population. Based on the frequency of fragile site induction, they are categorized as common and rare fragile sites. Common fragile sites are sensitive to replication stress and often rearra...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5330-5
更新日期:2019-04-18 00:00:00
abstract:BACKGROUND:Identifying causative mutations or genes through which quantitative trait loci (QTL) act has proven very difficult. Using information such as gene expression may help to identify genes and mutations underlying QTL. Our objective was to identify regions associated both with production traits or fertility and ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5656-7
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:The tetraploid durum wheat (Triticum turgidum L. ssp. durum Desf. Husnot) is an important crop which provides the raw material for pasta production and a valuable source of genetic diversity for breeding hexaploid wheat (Triticum aestivum L.). Future breeding efforts to enhance yield potential and climate re...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5645-x
更新日期:2019-04-10 00:00:00
abstract:BACKGROUND:Previously, we could show that L-lactate affects cultured bovine granulosa cells (GC) in a specific manner driving the cells into an early pre-ovulatory phenotype. Here we studied genome wide effects in L-lactate-treated GC to further elucidate the underlying mechanisms that are responsible for the L-lactate...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5657-6
更新日期:2019-04-05 00:00:00
abstract:BACKGROUND:Metagenomic sequencing is a powerful technology for studying the mixture of microbes or the microbiomes on human and in the environment. One basic task of analyzing metagenomic data is to identify the component genomes in the community. This task is challenging due to the complexity of microbiome composition...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5467-x
更新日期:2019-04-04 00:00:00
abstract:BACKGROUND:Determination of genome-wide DNA methylation is significant for both basic research and drug development. As a key epigenetic modification, this biochemical process can modulate gene expression to influence the cell differentiation which can possibly lead to cancer. Due to the involuted biochemical mechanism...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5488-5
更新日期:2019-04-04 00:00:00
abstract:BACKGROUND:Bananas (Musa spp.) are an important crop worldwide. Most modern cultivars resulted from a complex polyploidization history that comprised three whole genome duplications (WGDs) shaping the haploid Musa genome, followed by inter- and intra-specific crosses between Musa acuminata and M. balbisiana (A and B ge...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5618-0
更新日期:2019-03-27 00:00:00
abstract:BACKGROUND:The most critical step in the pearl formation during aquaculture is issued to the proliferation and differentiation of outer epithelial cells of mantle graft into pearl sac. This pearl sac secretes various matrix proteins to produce pearls by a complex physiological process which has not been well-understood...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5579-3
更新日期:2019-03-25 00:00:00
abstract:BACKGROUND:Of the hundreds of Vibrio cholerae serogroups, O1 and O139 are the main epidemic-causing ones. Although non-O1/non-O139 serogroups rarely cause epidemics, the possibility exists for strains within them to have pathogenic potential. RESULTS:We selected 25 representative strains within 16 V. cholerae serogrou...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5603-7
更新日期:2019-03-25 00:00:00
abstract:BACKGROUND:After polyploidization, a genome may experience large-scale genome-repatterning, featuring wide-spread DNA rearrangement and loss, and often chromosome number reduction. Grasses share a common tetraploidization, after which the originally doubled chromosome numbers reduced to different chromosome numbers amo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5566-8
更新日期:2019-03-07 00:00:00
abstract:BACKGROUND:Incilaria (= Meghimatium) fruhstorferi is an air-breathing land slug found in restricted habitats of Japan, Taiwan and selected provinces of South Korea (Jeju, Chuncheon, Busan, and Deokjeokdo). The species is on a decline due to depletion of forest cover, predation by natural enemies, and collection. To fac...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5526-3
更新日期:2019-02-26 00:00:00
abstract:BACKGROUND:Sclerotinia sclerotiorum is a broad-host range necrotrophic pathogen which is the causative agent of Sclerotinia stem rot (SSR), and a major disease of soybean (Glycine max). A time course transcriptomic analysis was performed in both compatible and incompatible soybean lines to identify pathogenicity and de...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5517-4
更新日期:2019-02-26 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) exhibit remarkable cell-type specificity and disease association. LncRNA's functional versatility includes epigenetic modification, nuclear domain organization, transcriptional control, regulation of RNA splicing and translation, and modulation of protein activity. However, mos...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5497-4
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:A key developmental transformation in the life of all vertebrates is the transition to sexual maturity, whereby individuals are capable of reproducing for the first time. In the farming of Atlantic salmon, early maturation prior to harvest size has serious negative production impacts. RESULTS:We report geno...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5525-4
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:Fruit peel colour is an important agronomic trait for fruit quality. Cytosine methylation plays an important role in gene regulation. Although the DNA methylation level of a single gene is important to affect the phenotype of mutation, there are large unknown of difference of the DNA methylation in plant and...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5499-2
更新日期:2019-02-07 00:00:00
abstract:BACKGROUND:Horses have been strongly selected for speed, strength, and endurance-exercise traits since the onset of domestication. As a result, highly specialized horse breeds have developed with many modern horse breeds often representing closed populations with high phenotypic and genetic uniformity. However, a great...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5484-9
更新日期:2019-02-04 00:00:00
abstract:BACKGROUND:Existing functional description of genes are categorical, discrete, and mostly through manual process. In this work, we explore the idea of gene embedding, distributed representation of genes, in the spirit of word embedding. RESULTS:From a pure data-driven fashion, we trained a 200-dimension vector represe...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5370-x
更新日期:2019-02-04 00:00:00
abstract:BACKGROUND:Environmental heterogeneity continuously produces a selective pressure that results in genomic variation among organisms; understanding this relationship remains a challenge in evolutionary biology. Here, we evaluated the degree of genome-environmental association of seven stonefly species across a wide geog...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5453-3
更新日期:2019-01-24 00:00:00
abstract:BACKGROUND:Alternative polyadenylation (APA) has emerged as a pervasive mechanism that contributes to the transcriptome complexity and dynamics of gene regulation. The current tsunami of whole genome poly(A) site data from various conditions generated by 3' end sequencing provides a valuable data source for the study o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5433-7
更新日期:2019-01-22 00:00:00
abstract:BACKGROUND:The orange pigmentation of the agar cultures of many Fusarium species is due to the production of carotenoids, terpenoid pigments whose synthesis is stimulated by light. The genes of the carotenoid pathway and their regulation have been investigated in detail in Fusarium fujikuroi. In this and other Fusarium...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5430-x
更新日期:2019-01-21 00:00:00
abstract:BACKGROUND:The nutritional value of soybean oil is largely influenced by the proportions of unsaturated fatty acids (FAs), including oleic acid (OA, 18:1), linoleic acid (LLA, 18:2), and linolenic acid (LNA, 18:3). Genome-wide association (GWAS) studies along with gene expression studies in soybean [Glycine max (L.) Me...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5449-z
更新日期:2019-01-21 00:00:00